![]() ![]() No significant difference in ESDR was found between A and F (p=0.15) or A and A+F (p=0.55). Of the remaining 1299 pts (A 434 F 431, A+F 434), 42% were cN1-3 and 73% were considered candidates for BCS. 63 pts were excluded (did not start NET). With 425 pts per arm, a one-tailed alpha = 0.025 chi-square test of two independent proportions has 84% power to detect an increase of ≥10% in ESDR for F or F+A compared to the A arm, assuming ESDR ≤30% in A. ESDR of each F arm was compared to that of the A alone arm. The primary endpoint of the neoadjuvant phase was ESDR. Pts with mPEPI 0 at surgery were recommended to continue assigned ET for 1.5 yrs followed by A for a total of 5 yrs ET (and not to receive CT). Elizabeth Healthcare, Edgewood, KY The University of Texas MD Anderson Cancer Center, Houston, TX Mayo Clinic, Department of Biostatistics, Rochester, MN Clinical Investigations Branch, National Cancer Institute, Bethesda, MD Dana-Farber Cancer Institute, Bethesda, MD Memorial Sloan Kettering Cancer Center, New York, NY Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA Dana-Farber Cancer Institute, Boston, MA University of North Carolina, Chapel Hill, NC Lester and Sue Smith Breast Center, Baylor Clinic, Baylor College of Medicine, Houston, TXīackground: For PM patients (pts) with locally advanced ER+ HER2- BC, NET improves breast conservation surgery (BCS) rates, and modified preoperative endocrine prognostic index (mPEPI) 0, defined as pT1-2 pN0 Ki6710% at wk 4 or 12 were recommended to go off protocol-directed ET and switch to CT. Louis, MO University of Chicago Medical Center, Chicago, IL St. Louis, MO Laredo Breast Care, Laredo, TX Washington University School of Medicine, St. Louis, MO Mayo Clinic, Rochester, MN The University of Texas Southwestern Medical Center, Dallas, TX Cedars Sanai Medical Center, Los Angeles, CA Washington University in St. He also stated that he has been heavily inspired by HBO's post-apocalyptic video-game adaptation The Last of Us for the world of I Am Legend 2.Washington University School of Medicine in St. ![]() Goldsman detailed that I Am Legend 2 is set several decades after the original and will explore the world long after " man's time as the dominant species" has ended. Speaking with Deadline, Akiva Goldsman, the co-writer of I Am Legend and the producer/writer of I Am Legend 2, has come to realize that the original movie's alternate ending was better than the original. ![]() Related: How I Am Legend Helped Make Dawn Of The Dead Neville sacrificing his life to allow Anna and Ethan to escape the Darkseekers in I Am Legend's theatrical cut completely misses the point of the ending of Matheson's novel. However, when he is (ironically) confronted with their humanity, he realizes that he has turned into the true monster. In the book, Neville views his violent methods with the vampires as necessary for his survival. Neville's survival is necessary for the themes of Richard Matheson's original novel to properly land. Not only is I Am Legend's alternate ending necessary for Will Smith's return in I Am Legend 2, but it is also the far better ending. Thus, with Will Smith's character only surviving in I Am Legend's alternate ending, it is necessary for I Am Legend 2 to pick up where that specific cut of the original movie leaves off. Neville then accompanies Anna and Ethan to Vermont, in hope of finding a surviving human colony. Instead of blowing everyone up, Neville apologizes for his horrifying actions and allows the Darkseekers to take the female Darkseeker away. I Am Legend's alternate ending follows this much more closely, with Neville finally understanding that the Darkseekers are not monsters, and simply want to save the Darkseeker that he is holding against her will. He finally recognizes that he is a terrifying legendary figure to the vampires, just as they once were to humans. The novel ends with Neville realizing that the undead vampires are simply the next evolutionary step, and wish to kill him simply because he has killed so many of them. However, I Am Legend's alternate ending sticks much closer to Richard Matheson's novel by having Neville survive. ![]()
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